A postdoctoral position is offered at the Oncogenes and Effector Targets Group of the Center for Applied Medical Research (CIMA-University of Navarra) within a project aimed at the identification of genetic and pharmacological approaches to target mutant KRAS tumors. The project is integrated in a priority research line focused on the discovery of oncogenic vulnerabilities and therapeutic strategies for the treatment of tumors with KRAS mutations (Vallejo A, Nat Comms, 2017; Ajona D, Cancer Disc, 2017; Roman M, Mol Cancer, 2018; Roman M, Cancer Res., 2018).
The project will require, among other tasks: generating cellular in vitro models and in vivo genetically-engineered mouse models using the CRISPR/Cas9 genome editing technology, as well as developing cell (proliferation, apoptosis and cell cycle analysis, immuno-histochemistry, immuno-fluorescence…) and molecular (RNAseq, proteomics, Western blot, qPCR, cloning) analyses for the validation of leads and for the characterization of the mechanism of action.
- PhD in biological or biomedical sciences obtained in the last 12 months (2018).
- Self-motivated, autonomous person with team work skills and ability to work in various projects.
- Background in Cancer Biology and Oncology is preferable.
- Training in animal work would be desirable.
- Experience in data set analysis and with computational tools would be advantageous.
- Publication record to compete for additional fellowship applications (e.g. Marie Curie actions, Juan de la Cierva, …)
The postdoctoral position is initially funded for 2 years (renewed annually) and could be extended for an additional year, pending on positive performance and available funding.
Interested applicants should send a cover letter describing past experience and interests, as well as their CV including at least two references to: firstname.lastname@example.org