Gastrointestinal Tumours

Coordinator: Josep Tabernero / Co-coordinator: Gabriel Capellá

The CIBERONC Digestive Tract Tumours programme mainly focusses on two of the neoplastic typologies with greatest social impact, due to their high rate of mortality and aggressiveness: cancer of the colon and of the pancreas.

Cancer of the colon is the most common in Spain considering both sexes and the second cause of death by cancer. The survival of patients of this type of cancer is closely connected with the stage of the diagnosis, not exceeding 20% when this is in stage IV.

Pancreatic ductal adenocarcinoma is furthermore one of the most aggressive cancers, the fourth cause of death by cancer in spite of representing only 10% of gastrointestinal tumours.

In spite of the great technological and scientific progress made over the last few years in the diagnosis and treatment of these pathologies, there are still some great clinical challenges which need to be tackled and solved as soon as possible.

Our programme has combined the potential of 11 research groups of acknowledged prestige, to tackle these challenges of great clinical relevance from experience in basic science.

Lines of research:

  • Molecular epidemiology and assessment of the risk of gastrointestinal cancer.
  • Characterisation of the tumour microenvironment.
  • Characterisation of personalised in vivo/ in vitro models in response to different treatments.
  • Clinical use of liquid biopsy.

Groups:

Main ResearcherConsortium InstitutionRegions
Josep M. Tabernero Instituto de Investigación Oncológica Vall d’Hebron Cataluña
Gabriel Capellá Instituto de Investigación Biomédica de Bellvitge-IDIBELL Cataluña
Eduardo Díaz-Rubio Hospital Clínico San Carlos Madrid
Manel Esteller Instituto de Investigación Biomédica de Bellvitge-IDIBELL Cataluña
Eduard Batlle Institut de Recerca Biomédica Cataluña
Enrique Aranda Hospital Universitario Reina Sofía de Córdoba Andalucía
Jaime Feliu Hospital La Paz Madrid
Alfredo Carrato Hospital Ramón y Cajal Madrid
Nuria Malats Centro Nacional de Investigaciones Oncológicas Madrid
Francisco X. Real Centro Nacional de Investigaciones Oncológicas Madrid
Andrés Cervantes Instituto de Investigación Sanitaria Valencia